2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-132018
    Bromo-PEG2-NHS ester 2148295-96-7
    Bromo-PEG2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG2-NHS ester
  • HY-138495
    F-PEG2-SO2-COOH
    F-PEG2-SO2-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    F-PEG2-SO2-COOH
  • HY-133499
    Boc-HyNic-PEG1-mal 2743657-82-9
    Boc-HyNic-PEG1-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-HyNic-PEG1-mal
  • HY-138350
    Azido-PEG10-CH2CO2-NHS
    Azido-PEG10-CH2CO2-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG10-CH2CO2-NHS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG10-CH2CO2-NHS
  • HY-140011
    Acid-C2-PEG3-NHS ester 1835759-79-9
    Acid-C2-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acid-C2-PEG3-NHS ester
  • HY-140478
    Boc-NH-PEG4-C3-acid 1416777-48-4
    Boc-N-amido-PEG4-C3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG4-C3-acid
  • HY-140405
    1-(t-Boc-Aminooxy)-3-aminooxy-propane 1352546-80-5
    1-(t-Boc-Aminooxy)-3-aminooxy-propane is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    1-(t-Boc-Aminooxy)-3-aminooxy-propane
  • HY-132075
    Methylamino-PEG3-acid 2148295-95-6
    Methylamino-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methylamino-PEG3-acid
  • HY-W043277
    m-PEG3-Tos 62921-74-8 98.75%
    m-PEG3-Tos is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277).
    m-PEG3-Tos
  • HY-140673
    m-PEG-acrylate (MW 30000)
    m-PEG-acrylate (MW 30000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-acrylate (MW 30000)
  • HY-W042501
    m-PEG5-Tos 80755-67-5
    m-PEG5-Tos is a derivative of silybin ethers, extracted from patent CN105037337A (compound III-c). m-PEG5-Tos is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277).
    m-PEG5-Tos
  • HY-130770
    Ald-CH2-PEG3-CH2-Boc 2100306-54-3
    Ald-CH2-PEG3-CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of SGK3 kinase PROTAC degrader.
    Ald-CH2-PEG3-CH2-Boc
  • HY-141161
    TCO-PEG8-acid 2353410-03-2
    TCO-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    TCO-PEG8-acid
  • HY-140772
    Azido-PEG6-PFP ester 1818294-47-1
    Azido-PEG6-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG6-PFP ester
  • HY-140346
    L-Azidohomoalanine 120042-14-0
    L-Azidohomoalanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-Azidohomoalanine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    L-Azidohomoalanine
  • HY-138737
    Propargyl-PEG7-Br
    Propargyl-PEG7-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG7-Br is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG7-Br
  • HY-132055
    Azido-PEG8-THP
    Azido-PEG8-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG8-THP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG8-THP
  • HY-132044
    Benzyl-PEG8-t-butyl ester
    Benzyl-PEG8-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG8-t-butyl ester
  • HY-140373
    Tos-PEG21-Tos
    Tos-PEG21-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG21-Tos
  • HY-129622
    NH2-PEG5-C6-Cl 1261238-22-5
    NH2-PEG5-C6-Cl (K-7) is a linker which refers to the PEG composition. NH2-PEG5-C6-Cl can be used in the synthesis of a series of compounds that induce degradation of intracellular molecules by autophagy.
    NH2-PEG5-C6-Cl
PROTAC Linkers Isoform Comparison

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